The Church of Santa Maria, dating back to the 16th century, overlooks Piazza Garibaldi. Inside, it houses Lorenzo Lotto's famous altarpiece depicting "The Assumption with Saints John the Baptist, Anthony, Mary Magdalene, and Joseph."

The Church of San Gregorio Magno, one of the most significant churches in Mogliano, has Franciscan origins and dates back to the 14th century. It overlooks Via Roma with its majestic staircase and imposing facade.

The Apollo Theater, built in the 19th century and overlooking Piazza Garibaldi, has been enhanced by several restoration projects. It hosts shows and events of historical and cultural significance.

The Museum of Sacred Art in Mogliano, inaugurated in 1979, houses paintings, statues, and reliquaries from churches in the area. It offers an evocative journey through the devotion and artistic evolution of the local community.

The Terre Artigiane Museum was created through a project inspired by Article 9 of the Italian Constitution, to promote the territory, craft production, and tourism in the municipalities of Mogliano, Loro Piceno, Petriolo, and Urbisaglia.

The history of Palazzo San Michele, built in the 18th century outside Porta Roma, is linked to the need for a hospital in Mogliano. The building preserves period rooms and paintings by Giambattista Fabiani, intended for social use.